In vitro release of amoxycillin from lipophilic suppositories
- Webster, Jessica A, Dowse, Roslind, Walker, Roderick B
- Authors: Webster, Jessica A , Dowse, Roslind , Walker, Roderick B
- Date: 1998
- Subjects: To be catalogued
- Language: English
- Type: text , article
- Identifier: http://hdl.handle.net/10962/184377 , vital:44213 , xlink:href="https://doi.org/10.3109/03639049809085636"
- Description: The in vitro release characteristics of amoxycillin from different lipophilic suppository bases were investigated using the USP rotating basket method. Suppositories containing 250 mg amoxycillin were prepared in theobroma oil and in the semisynthetic bases Witepsol W35, Suppocire A32, Novata BD, and Novata 299. Both freshly prepared and 1-month-old suppositories were tested. Analysis of amoxycillin was performed using a validated high-performance liquid chromatographic (HPLC) technique. Release profiles differed significantly between bases, with the greatest amount of amoxycillin being released from both newly made and 1-month-old Novata BD bases (87.57 ± 8.18 and 99.66 ± 6.63%, respectively), and the lowest amount released from the newly manufactured theobroma suppositories (8.82 ± 0.75%) and the 1-month-old Suppocire A32 suppositories (7.78 ± 0.27%).
- Full Text:
- Date Issued: 1998
- Authors: Webster, Jessica A , Dowse, Roslind , Walker, Roderick B
- Date: 1998
- Subjects: To be catalogued
- Language: English
- Type: text , article
- Identifier: http://hdl.handle.net/10962/184377 , vital:44213 , xlink:href="https://doi.org/10.3109/03639049809085636"
- Description: The in vitro release characteristics of amoxycillin from different lipophilic suppository bases were investigated using the USP rotating basket method. Suppositories containing 250 mg amoxycillin were prepared in theobroma oil and in the semisynthetic bases Witepsol W35, Suppocire A32, Novata BD, and Novata 299. Both freshly prepared and 1-month-old suppositories were tested. Analysis of amoxycillin was performed using a validated high-performance liquid chromatographic (HPLC) technique. Release profiles differed significantly between bases, with the greatest amount of amoxycillin being released from both newly made and 1-month-old Novata BD bases (87.57 ± 8.18 and 99.66 ± 6.63%, respectively), and the lowest amount released from the newly manufactured theobroma suppositories (8.82 ± 0.75%) and the 1-month-old Suppocire A32 suppositories (7.78 ± 0.27%).
- Full Text:
- Date Issued: 1998
Pictograms in pharmacy:
- Dowse, Roslind, Ehlers, Martina S
- Authors: Dowse, Roslind , Ehlers, Martina S
- Date: 1998
- Language: English
- Type: text , article
- Identifier: http://hdl.handle.net/10962/157048 , vital:40082 , https://0-doi.org.wam.seals.ac.za/10.1111/j.2042-7174.1998.tb00924.x
- Description: This review examines the use of pictograms in health care. Well designed pictograms are simple, clear, graphic symbols able to convey their intended meaning to all patients, including those who are illiterate, elderly or visually impaired. Although some research on the effectiveness of pictograms has not supported the hypothesis that pictograms are beneficial for the acquisition and comprehension of information, most studies investigating health‐related applications of pictograms have shown them to be of benefit in the comprehension and recall of instructions on prescription and over‐the‐counter medicines. However, the success of pictograms as a communication aid in pharmacy depends first on a rigorous design process, followed by well‐designed, randomised, controlled trials using an appropriate method of evaluation. The final stage is to investigate the optimal way of using pictograms in practice and to assess their effect on behavioural outcomes, such as compliance.
- Full Text:
- Date Issued: 1998
- Authors: Dowse, Roslind , Ehlers, Martina S
- Date: 1998
- Language: English
- Type: text , article
- Identifier: http://hdl.handle.net/10962/157048 , vital:40082 , https://0-doi.org.wam.seals.ac.za/10.1111/j.2042-7174.1998.tb00924.x
- Description: This review examines the use of pictograms in health care. Well designed pictograms are simple, clear, graphic symbols able to convey their intended meaning to all patients, including those who are illiterate, elderly or visually impaired. Although some research on the effectiveness of pictograms has not supported the hypothesis that pictograms are beneficial for the acquisition and comprehension of information, most studies investigating health‐related applications of pictograms have shown them to be of benefit in the comprehension and recall of instructions on prescription and over‐the‐counter medicines. However, the success of pictograms as a communication aid in pharmacy depends first on a rigorous design process, followed by well‐designed, randomised, controlled trials using an appropriate method of evaluation. The final stage is to investigate the optimal way of using pictograms in practice and to assess their effect on behavioural outcomes, such as compliance.
- Full Text:
- Date Issued: 1998
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