Synthesis and structure determination of 8-and 9-iodocamphorquinone bis (ethylene ketal)
- Magqi, Nceba, Lobb, Kevin A, Kaye, Perry T, Caira, Mino R
- Authors: Magqi, Nceba , Lobb, Kevin A , Kaye, Perry T , Caira, Mino R
- Date: 2007
- Subjects: To be catalogued
- Language: English
- Type: text , article
- Identifier: http://hdl.handle.net/10962/449399 , vital:74817 , xlink:href="https://doi.org/10.3184/030823407X209"
- Description: The structures of 8- and 9-iodocamphorquinone bis(ethylene ketal) have been confirmed by spectroscopic and single crystal X-ray analysis. The unexpected formation of the latter isomer is attributed to intramolecular rearrangement of the camphor skeleton, the mechanistic details of which have been explored using coset analysis.
- Full Text:
- Date Issued: 2007
- Authors: Magqi, Nceba , Lobb, Kevin A , Kaye, Perry T , Caira, Mino R
- Date: 2007
- Subjects: To be catalogued
- Language: English
- Type: text , article
- Identifier: http://hdl.handle.net/10962/449399 , vital:74817 , xlink:href="https://doi.org/10.3184/030823407X209"
- Description: The structures of 8- and 9-iodocamphorquinone bis(ethylene ketal) have been confirmed by spectroscopic and single crystal X-ray analysis. The unexpected formation of the latter isomer is attributed to intramolecular rearrangement of the camphor skeleton, the mechanistic details of which have been explored using coset analysis.
- Full Text:
- Date Issued: 2007
Transformations of manool. Tri-and tetracyclic norditerpenoids with in vitro activity against plasmodium falciparum
- van Wyk, Albert W W, Lobb, Kevin A, Mino, Caira R, Hoppe, Heinrich C, Davies-Coleman, Michael T
- Authors: van Wyk, Albert W W , Lobb, Kevin A , Mino, Caira R , Hoppe, Heinrich C , Davies-Coleman, Michael T
- Date: 2007
- Subjects: To be catalogued
- Language: English
- Type: text , article
- Identifier: http://hdl.handle.net/10962/450511 , vital:74956 , xlink:href="https://doi.org/10.1021/np0701071"
- Description: The known 17-norisopimar-15-ene-8‚,13‚-diol (5) and five new semisynthetic norditerpenoids, ethyl 17-norabiet-13-(15)-E-en-8‚-ol-16-oate (6), ethyl 17-norabiet-13(15)-Z-en-8‚-ol-16-oate (7), 17-norpimaran-13R-ethoxy-8,16-olactone(8), 17-norisopimarane-8‚,15-diol (9), and 17-norarabiet-13(15)-ene-8‚,16-diol (10), were prepared from manool (11).Standard spectroscopic data including X-ray crystal analysis were used to determine the structures of5-10. All fivecompounds exhibited in Vitroantiplasmodial activity against the malarial parasitePlasmodium falciparumat varyingÌgmL-1concentrations.
- Full Text:
- Date Issued: 2007
- Authors: van Wyk, Albert W W , Lobb, Kevin A , Mino, Caira R , Hoppe, Heinrich C , Davies-Coleman, Michael T
- Date: 2007
- Subjects: To be catalogued
- Language: English
- Type: text , article
- Identifier: http://hdl.handle.net/10962/450511 , vital:74956 , xlink:href="https://doi.org/10.1021/np0701071"
- Description: The known 17-norisopimar-15-ene-8‚,13‚-diol (5) and five new semisynthetic norditerpenoids, ethyl 17-norabiet-13-(15)-E-en-8‚-ol-16-oate (6), ethyl 17-norabiet-13(15)-Z-en-8‚-ol-16-oate (7), 17-norpimaran-13R-ethoxy-8,16-olactone(8), 17-norisopimarane-8‚,15-diol (9), and 17-norarabiet-13(15)-ene-8‚,16-diol (10), were prepared from manool (11).Standard spectroscopic data including X-ray crystal analysis were used to determine the structures of5-10. All fivecompounds exhibited in Vitroantiplasmodial activity against the malarial parasitePlasmodium falciparumat varyingÌgmL-1concentrations.
- Full Text:
- Date Issued: 2007
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